Mailing Address: Department of Biological Sciences 212 Biological Sciences Building 50 Sifton Road University of Manitoba Winnipeg, Manitoba R3T 2N2 CANADA
Lab Location: Buller Building, Room 316 and 319 45 Chancellors Circle University of Manitoba, Fort Garry Campus.
Office Phone: 204-474-9730 Lab Phone: 204-474-9198 Fax: (204)-474-7604 email: Judith.Anderson@umanitoba.ca
Research InterestsCell and Development, muscle regeneration, muscle satellite/stem cell biology, comparative development and regulation in skeletal muscle, neuromuscular junctions, regulation of activation by nitric oxide, HGF- cmetR signaling in satellite cell activation, fiber cytoskeleton, age-related atrophy
- Gigliotti D, Leiter JRS, Macek B, Davidson MJ, MacDonald PB, Anderson JE (2015). Atrophy, inducible satellite cell activation and possible denervation of supraspinatus muscle in injured human rotator-cuff muscle. Amer J Physiol Cell Physiol 309, 383-391. full text of article
- Sakaguchi S, Shono J-i, Suzuki T, Do M-K Q, Mizunoya W, Nakamura M, Sato Y, Furuse M, Yamada K, Ikeuchi Y, Anderson JE, Tatsumi R. (2014). Anti-inflammatory macrophages may promote myoblast migration and neural chemorepellent Semaphorin 3A expression at the early-differentiation phase of muscle regeneration. International Journal of Biochemistry & Cell Biology 54, 272-285.
- Sharma P, Basu S, Mitchell RW, Stelmack GL, Anderson JE, Halayko AJ. (2014). Role of dystrophin in airway smooth muscle phenotype, contraction and lung function. PLoS ONE 9, e102737.
- Snow WM, Anderson JE, Fry M. (2014). Regional and genotypic differences in intrinsic electrophysiological properties of cerebellar Purkinje neurons from wild-type and dystrophin-deficient mdx mice. Neurobiology of Learning & Memory 107, 19-31.
- Thomas MM, Wang DC, D’Souza DM, Krause MP, Layne AS, Criswell DS, O’Neill HM, Connor MK, Anderson JE, Kemp BE, Steinberg GR, Hawke TJ. (2014). Muscle-Specific AMPK β1β2-null mice display a myopathy resultant from impairments in blood flow. FASEB Journal 28 (2098-2107).
Research projects in the lab include experiments that examine:
- processes of satellite cell activation in normal, old and regenerating skeletal muscles
- regulation of satellite cell activation and quiescence in different species (fish, mouse, human)
- cytoskeletal proteins and muscle fiber stability in development and disease
- human muscle disease pathophysiology and response to treatment
- muscle-specific responses in relation to outcomes of disease and treatment
- in vivo studies of muscle responses to Nitric Oxide-donor drugs and exercise in dystrophy and aging
- in vivo studies of re-innervation during muscle regeneration
Topics such as the mechanisms of cell injury in normal and dystrophic muscle, compensatory muscle regeneration and hypertrophy, and the effects of various therapies or voluntary exercise on muscle repair, satellite cell activation, muscle growth, bone density and age-related atrophy are examined using a large variety of cellular, molecular and whole-animal in vivo assays of function. In human studies, the measures are clinical assessment techniques and in vitro assays of biopsy-muscle status, cell proliferation, and gene expression.
Students receive training with a ‘systems’ biology approach through courses, bench work, lab discussions and publications spanning a broad range of muscle-biology questions using studies at the level of single cells, tissues, animals and humans. Education research has the goal to help improve health care through interprofessional learning.
Studies of satellite cell activation via nitric oxide have opened an exciting area of research on muscle regeneration, growth and the muscle-fiber cytoskeleton that integrates mechanical and biochemical signal transduction with cell and molecular biology of muscle tissue in growth, development, disease, aging and evolution.